Identification of a RIPK2-Regulated Gene Signature as a Candidate Biomarker for RIPK2 Activity and Prognosis in Prostate Cancer

Abstract excerpt

<h4>ABSTRACT</h4> Receptor-interacting protein kinase 2 (RIPK2) has emerged as a promising drug target in various cancers, including prostate cancer (PC). However, the absence of reliable biomarkers to assess RIPK2 activity limits both patient selection for anti-RIPK2 therapies and treatment monitoring. To address this gap, we performed RNA-Seq analysis on PC cell lines (22Rv1, DU145, and PC3) with CRISPR/Cas9-me...

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• Autophagy in Disease and Therapy
• Cancer Immunotherapy and Biomarkers
• Cancer Mechanisms and Therapy
• Cell death mechanisms and regulation
• Circular RNAs in diseases
• Ferroptosis and cancer prognosis
• interferon and immune responses
• NF-κB Signaling Pathways

Identifiers and source

Literature Corpus work

f63859ff-28a4-5437-80d4-3f592068dd74

DOI

10.1101/2025.04.30.651490