Article

Streptococcus anginosus induces macrophage pyroptosis and drives gastric "inflammation-to-cancer" transition by activating the NLRP3/IL-1β signaling pathway

2026-04-23

Abstract excerpt

<title>Abstract</title> <p> <bold>Background</bold> Streptococcus anginosus (SA) is enriched in the gastric cancer (GC) microenvironment and correlates with GC risk, but its mechanism in the "inflammation-to-cancer" transition is unclear. This study investigates whether SA induces macrophage pyroptosis through the NLRP3/IL-1β signaling pathway, promoting this transition. <bold>Methods</bold> Tissue samples fr...

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Literature Corpus work: 114859c9-b439-511a-a58c-dcff6a3a2012
DOI: 10.21203/rs.3.rs-9269296/v1

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