Article

A proteomic polygenic score to identify IL-18 driven inflammatory bowel disease

2026-05-21

Abstract excerpt

High levels of IL-18 have been causally implicated in IBD risk and may represent a unique mechanism driving IBD yet to be therapeutically targeted. To identify individuals predisposed to increased levels of IL-18, we implemented a polygenic approach to predict IL-18 plasma protein levels. Using a dataset with over 50,000 individuals with both genetic and plasma protein levels from Olink, we developed a 27 SNP poly...

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Literature Corpus work: b2e4c8ab-a708-51e1-b70e-faa623508035
DOI: 10.64898/2026.05.18.26353508

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