Article

Allogeneic Tumor Cell-Derived Extracellular Vesicles Stimulate CD8 T Cell Response in Colorectal Cancer

2023-04-18

Abstract excerpt

<h4>ABSTRACT</h4> Colorectal Cancer (CRC) is the second leading cause of cancer-related death in the United States. Most CRC patients present with a microsatellite stable (MSS) phenotype and are highly resistant to immunotherapies. Tumor extracellular vesicles (TEVs), secreted by tumor cells, can contribute to intrinsic resistance to immunotherapy in CRC. We previously showed that autologous TEVs without function...

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Literature Corpus work: b2a5d89a-53f0-521a-96b2-da516fecc40c
DOI: 10.1101/2023.04.17.537250

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