Article
Limited Intrahost Diversity and Background Evolution Accompany 40 Years of Canine Parvovirus Host Adaptation and Spread.
Journal of virology - 12 Dec 2019
Voorhees Ian E H, Lee Hyunwook, Allison Andrew B, Lopez-Astacio Robert, Goodman Laura B, Oyesola Oyebola O, Omobowale Olutayo, Fagbohun Olusegun, Dubovi Edward J, Hafenstein Susan L, Holmes Edward C, Parrish Colin R
Abstract excerpt
Canine parvovirus (CPV) is a highly successful pathogen that has sustained pandemic circulation in dogs for more than 40 years. Here, integrating full-genome and deep-sequencing analyses, structural information, and in vitro experimentation, we describe the macro- and microscale features that accompany CPV's evolutionary success. Despite 40 years of viral evolution, all CPV variants are more than ∼99% identical...
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