Article

NFATc2 potentiates DNA double-strand breaks repair by interaction with Ku80 in radiotherapy patients

2026-07-30

Abstract excerpt

A fraction of patients treated with radiotherapy are known to be more sensitive to ionizing radiations. Skin fibroblasts from such radiosensitive individuals exhibit a higher cellular toxicity after irradiation and a delay in DNA repair. Deciphering the molecular mechanisms underlying these cellular defects is thus of major importance. We previously observed that the transcription factor NFATc2 is expressed at a r...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b263f2cf-8545-5746-be22-60f69635d6bb
DOI: 10.64898/2026.07.30.741465

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

NFATc2 potentiates DNA double-strand breaks repair by interaction with Ku80 in radiotherapy patientsDOI 10.64898/2026.07.30.741465Read

NF-κB regulates DNA double-strand break repair in conjunction with BRCA1–CtIP complexesSemantic proximity Read

Fibroblasts from Retinoblastoma Patients Show Radiosensitivity Linked to Abnormal Localization of the ATM ProteinSemantic proximity Read

Novel Function of Transcription Factor TTF1 in UV Mediated DNA Damage Repair in Mammalian CellsSemantic proximity Read

Critical Role of Monoubiquitination of Histone H2AX Protein in Histone H2AX Phosphorylation and DNA Damage ResponseSemantic proximity Read

A Double-Strand Break Repair Defect in ATM-Deficient Cells Contributes to RadiosensitivitySemantic proximity Read

Improved identification of DNA double strand breaks: γ-H2AX-epitope visualization by confocal microscopy and 3D reconstructed imagesSemantic proximity Read

The NEK1 interactor, C21ORF2, is required for efficient DNA damage repairSemantic proximity Read

Phosphorylation of H2A.XTyr39 positively regulates DNA damage response and is linked to cancer progression.Semantic proximity Read

Compromised repair of radiation-induced DNA double-strand breaks in Fanconi anemia fibroblasts in G2.Semantic proximity Read

Restricted Heterochromatin Formation Links NFATc2 Repressor Activity With Growth Promotion in Pancreatic CancerSemantic proximity Read

The TMPRSS2–ERG Gene Fusion Blocks XRCC4-Mediated Nonhomologous End-Joining Repair and Radiosensitizes Prostate Cancer Cells to PARP InhibitionSemantic proximity Read

Epithelial-to-mesenchymal transition and NF-kB pathways are promoted by a mutant form of DDB2, unable to bind PCNA, in UV-damaged human cells.Semantic proximity Read