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Article

Mutations responsible for MYH9-related thrombocytopenia impair SDF-1-driven migration of megakaryoblastic cells.

Thrombosis and haemostasis - 1 Oct 2011

Pecci Alessandro, Bozzi Valeria, Panza Emanuele, Barozzi Serena, Gruppi Cristian, Seri Marco, Balduini Carlo L

Abstract excerpt

MYH9-related disease (MYH9-RD) is an autosomal-dominant thrombocytopenia caused by mutations in the gene for the heavy chain of non-muscle myosin-IIA (NMMHC-IIA). Recent in vitro studies led to the hypothesis that thrombocytopenia of MYH9-RD derives from an ectopic platelet release by megakaryocytes in the osteoblastic areas of bone marrow (BM), which are enriched in type I collagen, rather than in vascular...

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Source

Identifiers

PMID: 21833445
DOI: 10.1160/TH11-02-0126

Genes

MYH9

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Mutations responsible for MYH9-related thrombocytopenia impair SDF-1-driven migration of megakaryoblastic cells.PMID 21833445Read ↗

Megakaryocyte migration defects due to nonmuscle myosin IIA mutations underlie thrombocytopenia in MYH9-related disease.Semantic proximity Read ↗

The abnormal proplatelet formation in MYH9-related macrothrombocytopenia results from an increased actomyosin contractility and is rescued by myosin IIA inhibition.Semantic proximity Read ↗

MYH9-Related Platelet DisordersSemantic proximity Read ↗

MYH-9 Related Platelet Disorders: Strategies for Management and DiagnosisSemantic proximity Read ↗

Altered cytoskeleton organization in platelets from patients with MYH9-related disease.Semantic proximity Read ↗

Reduced platelet forces underlie impaired hemostasis in mouse models of <i>MYH9</i> -related diseaseSemantic proximity Read ↗

Dysmegakaryopoiesis of FPD/AML pedigrees with constitutional RUNX1 mutations is linked to myosin II deregulated expression.Semantic proximity Read ↗

Pathogenetic mechanisms of hematological abnormalities of patients with MYH9 mutations.Semantic proximity Read ↗

Linking the Landscape of MYH9-Related Diseases to the Molecular Mechanisms that Control Non-Muscle Myosin II-A Function in Cells.Semantic proximity Read ↗

Advances in the understanding of MYH9 disorders.Semantic proximity Read ↗

Outside-In Signalling Generated by a Constitutively Activated Integrin αIIbβ3 Impairs Proplatelet Formation in Human MegakaryocytesSemantic proximity Read ↗

Regulation of platelet myosin light chain (MYL9) by RUNX1: implications for thrombocytopenia and platelet dysfunction in RUNX1 haplodeficiencySemantic proximity Read ↗

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