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Article

Altered cytoskeleton organization in platelets from patients with MYH9-related disease.

Journal of thrombosis and haemostasis : JTH - 1 May 2005

Canobbio I, Noris P, Pecci A, Balduini A, Balduini C L, Torti M

Abstract excerpt

MYH9-related disease (MYH9-RD) is an autosomal dominant disorder deriving from mutations in the MYH9 gene encoding for the heavy chain of non-muscle myosin IIA, and characterized by thrombocytopenia and giant platelets. Isoform IIA of myosin is the only one expressed in platelets, but the possibility that MYH9 mutations affect the organization of contractile structures in these blood elements has never been...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15869600
DOI: 10.1111/j.1538-7836.2005.01244.x

Genes

MYH9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Altered cytoskeleton organization in platelets from patients with MYH9-related disease.PMID 15869600Read ↗

MYH9-Related Platelet DisordersSemantic proximity Read ↗

The membrane skeleton density of red blood cells in <i>MYH9</i> -related disease patients is decreasedSemantic proximity Read ↗

MYH-9 Related Platelet Disorders: Strategies for Management and DiagnosisSemantic proximity Read ↗

Linking the Landscape of MYH9-Related Diseases to the Molecular Mechanisms that Control Non-Muscle Myosin II-A Function in Cells.Semantic proximity Read ↗

Mutations responsible for MYH9-related thrombocytopenia impair SDF-1-driven migration of megakaryoblastic cells.Semantic proximity Read ↗

Megakaryocyte Cytoskeletal Proteins in Platelet Biogenesis and DiseasesSemantic proximity Read ↗

MYH9‐related disease mutations cause abnormal red blood cell morphology through increased myosin‐actin binding at the membraneSemantic proximity Read ↗

The abnormal proplatelet formation in MYH9-related macrothrombocytopenia results from an increased actomyosin contractility and is rescued by myosin IIA inhibition.Semantic proximity Read ↗

Reduced platelet forces underlie impaired hemostasis in mouse models of <i>MYH9</i> -related diseaseSemantic proximity Read ↗

Megakaryocyte migration defects due to nonmuscle myosin IIA mutations underlie thrombocytopenia in MYH9-related disease.Semantic proximity Read ↗

A familial case of MYH9 gene mutation associated with multiple functional and structural platelet abnormalities.Semantic proximity Read ↗

Clinical, pathological, and genetic analysis of ten patients with MYH9-related disease.Semantic proximity Read ↗

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