Article

A positive feedback loop: RAD18-YAP-TGF-β between triple-negative breast cancer and macrophages regulates cancer stemness and progression

2022-04-12

Abstract excerpt

Abstract As a key regulator of the DNA translesion synthesis (TLS) pathway, RAD18 is error-prone and contributes to the accumulation of DNA mutations. Our previous study showed that it plays an essential role in the progression of multiple tumors. However, the mechanism through which RAD18 influences triple-negative breast cancer (TNBC), especially the interaction between tumor cells and the tumor microenvironment...

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Literature Corpus work: b253d0d3-14f5-5548-88fc-01f2e002017a
DOI: 10.1038/s41420-022-00968-9

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A positive feedback loop: RAD18-YAP-TGF-β between triple-negative breast cancer and macrophages regulates cancer stemness and progressionDOI 10.1038/s41420-022-00968-9Read

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