Article

The TUDOR domain of SMN is an H3K79 <sup>me1</sup> histone mark reader

2022-10-11

Abstract excerpt

Spinal Muscle Atrophy (SMA) is the leading genetic cause of infant mortality and results from the loss of functional Survival Motor Neuron (SMN) protein by either deletion or mutation of the SMN1 gene. SMN is characterized by a central TUDOR domain, which mediates the association of SMN with arginine methylated (R me ) partners, such as COILIN, FIBRILLARIN, and RNApolII. Herein, we biochemically demonstrate that...

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Literature Corpus work: b20cae1c-b10a-5f82-ad0e-90e04cab5e51
DOI: 10.1101/2022.10.06.511070

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