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Article

HuD interacts with survival motor neuron protein and can rescue spinal muscular atrophy-like neuronal defects.

Human molecular genetics - 1 Feb 2011

Hubers Lisa, Valderrama-Carvajal Hector, Laframboise Janik, Timbers Janie, Sanchez Gabriel, Côté Jocelyn

Abstract excerpt

Spinal muscular atrophy is an autosomal-recessive neuromuscular disease caused by disruption of the survival of motor neuron (SMN) gene, which promotes cytoplasmic assembly of the splicing core machinery. It remains unclear how a deficiency in SMN results in a disorder leading to selective degeneration of lower motor neurons. We report here that SMN interacts with RNA-binding protein HuD in neurites of...

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Source

Identifiers

PMID: 21088113
DOI: 10.1093/hmg/ddq500

Genes

CARM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

HuD interacts with survival motor neuron protein and can rescue spinal muscular atrophy-like neuronal defects.PMID 21088113Read ↗

A novel function for the survival motoneuron protein as a translational regulatorSemantic proximity Read ↗

The tudor protein survival motor neuron (SMN) is a chromatin-binding protein that interacts with methylated histone H3 lysine 79Semantic proximity Read ↗

Essential Role for the Tudor Domain of SMN in Spliceosomal U snRNP Assembly: Implications for Spinal Muscular AtrophySemantic proximity Read ↗

KH-type splicing regulatory protein interacts with survival motor neuron protein and is misregulated in spinal muscular atrophy.Semantic proximity Read ↗

A novel role for CARM1 in promoting nonsense-mediated mRNA decay: potential implications for spinal muscular atrophySemantic proximity Read ↗

Identification of survival motor neuron as a transcriptional activator-binding proteinSemantic proximity Read ↗

Survival motor neuron (SMN) protein interacts with transcription corepressor mSin3A.Semantic proximity Read ↗

A high-throughput genome-wide RNAi screen identifies modifiers of survival motor neuron proteinSemantic proximity Read ↗

The TUDOR domain of SMN is an H3K79 <sup>me1</sup> histone mark readerSemantic proximity Read ↗

The Survival of Motor Neuron Protein Acts as a Molecular Chaperone for mRNP AssemblySemantic proximity Read ↗

Survival motor neuron protein regulates stem cell division, proliferation, and differentiation in Drosophila.Semantic proximity Read ↗

Smn, the spinal muscular atrophy–determining gene product, modulates axon growth and localization of β-actin mRNA in growth cones of motoneuronsSemantic proximity Read ↗

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