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Article

The Survival of Motor Neuron Protein Acts as a Molecular Chaperone for mRNP Assembly

1 Feb 2017

Abstract excerpt

Spinal muscular atrophy (SMA) is a motor neuron disease caused by reduced levels of the survival of motor neuron (SMN) protein. SMN is part of a multiprotein complex that facilitates the assembly of spliceosomal small nuclear ribonucleoproteins (snRNPs). SMN has also been found to associate with mRNA-binding proteins, but the nature of this association was unknown. Here, we have employed a combination of...

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PMID: 28199839
DOI: 10.1016/j.celrep.2017.01.059

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