Wutou decoction ameliorates rheumatoid arthritis through inhibiting hypoxia-induced invasive phenotype of fibroblast-like synoviocytes mediated by the Notch pathway.

Abstract excerpt

ETHNOPHARMACOLOGICAL RELEVANCE: Despite its long history of use in traditional medicine for joint disorders, Wutou Decoction (WTD) has not been widely adopted as a complementary therapy for rheumatoid arthritis (RA) in modern practice. This is primarily due to a lack of robust pharmacological evidence and a clear understanding of its mechanisms of action. Further investigation into the mechanistic basis of WTD is...

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