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Targeted activation on Bnip3 enhances mitophagy to prevent the progression of osteoarthritis

1 Mar 2025

Abstract excerpt

Background: The production of reactive oxygen species (ROS) and mitochondrial dysfunction in chondrocytes are closely related to cartilage degeneration in the procedure of osteoarthritis (OA). Mitophagy is responsible for the scavenging of ROS and dysfunctional mitochondria and is considered a key therapeutic target for the treatment of OA. Tiopronin, a classic thiol antioxidant, has been widely studied for the...

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PMID: 40190344
DOI: 10.1016/j.jot.2025.01.012

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