Article

Sex-specific recombination predicts parent of origin for recurrent genomic disorders

2020-08-13

Abstract excerpt

<title>Abstract</title> <p>Genomic disorders are caused by structural rearrangements of the genome that generally occur during meiosis. Often the rearrangements result in large-scale (> 1 kb) copy number variants (CNV; deletions or duplications ≥ 1 kb). Recurrent pathogenic CNVs harbor similar breakpoints in multiple unrelated individuals and are primarily formed via non-allelic homologous recombination (NAHR). S...

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Literature Corpus work: b18cb11d-0715-5eaf-8b17-01ce1b3b7264
DOI: 10.21203/rs.3.rs-50150/v1

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