Back to search

Article

Copper trafficking in <i>Trypanosoma cruzi</i> : the transcriptional response of candidates to balance toxicity and recruitment

2024-04-12

Abstract excerpt

Trypanosoma cruzi (Chagas disease) depends on acquiring nutrients and cofactors, like copper (Cu), from its hosts. Cu is essential for aerobic organisms, but it can also be toxic, so its transport and storage must be regulated. In the present study, we characterized the effects of changes in Cu availability on growth, intracellular ion content, and oxygen consumption. Our results show that Cu is essential for epim...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
b18c90f9-c50d-5389-a04a-85f3680f243b
DOI
10.1101/2024.04.12.589278
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Copper trafficking in <i>Trypanosoma cruzi</i> : the transcriptional response of candidates to balance toxicity and recruitmentDOI 10.1101/2024.04.12.589278
Iron metabolism in trypanosomatids, and its crucial role in infectionSemantic proximity
Transcriptomic response to different heme sources in <i>Trypanosoma cruzi</i>Semantic proximity
Transcriptomic analysis reveals metabolic switches and surface remodeling as key processes for stage transition in <i>Trypanosoma cruzi</i>Semantic proximity
Novel aspects of iron homeostasis in pathogenic bloodstream form <i>Trypanosoma brucei</i>Semantic proximity
Adaptive iron utilization compensates for the lack of an inducible uptake system in <i>Naegleria fowleri</i> and represents a potential target for therapeutic interventionSemantic proximity
Molecular mechanisms of copper homeostasis.Semantic proximity
Metal ion metabolism. The copper-iron connection.Semantic proximity
Mycobacterium tuberculosis and Copper: A Newly Appreciated Defense against an Old Foe?Semantic proximity
TcZC3HTTP, a regulatory element that contributes to <i>Trypanosoma cruzi</i> cell proliferationSemantic proximity
Pathogenic adaptations to host-derived antibacterial copperSemantic proximity
Manganese Homeostasis Drives <i>Stenotrophomonas maltophilia</i> Oxidative Stress Defense and Replication in <i>Acanthamoeba castellanii</i> phagosomesSemantic proximity
The mRNAs associated to a zinc finger protein fromTrypanosoma cruzishift during stress conditionsSemantic proximity
Select a neighboring publication to make it the new centre.