Back to search

Article

Analysis of blood and nasal epithelial transcriptomes to identify mechanisms associated with control of SARS-CoV-2 viral load in the upper respiratory tract

2023-03-13

Abstract excerpt

<h4>Background</h4> The amount of SARS-CoV-2 detected in the upper respiratory tract (URT viral load) is a key driver of transmission of infection. Current evidence suggests that mechanisms constraining URT viral load are different from those controlling lower respiratory tract viral load and disease severity. Understanding such mechanisms may help to develop treatments and vaccine strategies to reduce transmissio...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
b149427f-5ebb-5927-a8b1-4d44a3b8bb0d
DOI
10.1101/2023.03.09.23287028
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Analysis of blood and nasal epithelial transcriptomes to identify mechanisms associated with control of SARS-CoV-2 viral load in the upper respiratory tractDOI 10.1101/2023.03.09.23287028
A multi-tissue study of immune gene expression profiling highlights the key role of the nasal epithelium in COVID-19 severitySemantic proximity
A multi-tissue study of immune gene expression profiling highlights the key role of the nasal epithelium in COVID-19 severitySemantic proximity
Transcriptomic dysregulations associated with SARS-CoV-2 infection in human nasopharyngeal and peripheral blood mononuclear cellsSemantic proximity
Identifying novel host-based diagnostic biomarker panels for COVID-19: a whole-blood/nasopharyngeal transcriptome meta-analysisSemantic proximity
Temporal High-Resolution Atlas of Human Blood Leukocyte Composition in Response to Respiratory Virus InoculationSemantic proximity
Single-cell multi-omics show disruption of blood and airway T-cells in pulmonary long COVIDSemantic proximity
Integrated analyses of single-cell RNA-seq public data reveal the gene regulatory network landscape of respiratory epithelial and peripheral immune cells in COVID-19 patientsSemantic proximity
Expression profile of HERVs and inflammatory mediators detected in nasal mucosa as a predictive biomarker of COVID-19 severitySemantic proximity
Human SARS-CoV-2 challenge uncovers local and systemic response dynamicsSemantic proximity
A curated collection of transcriptome datasets to study the transcriptional response in blood and nasal samples following viral respiratory inoculation and vaccinationSemantic proximity
Upper airway gene expression differentiates COVID-19 from other acute respiratory illnesses and reveals suppression of innate immune responses by SARS-CoV-2Semantic proximity
Impaired local intrinsic immunity to SARS-CoV-2 infection in severe COVID-19Semantic proximity
Select a neighboring publication to make it the new centre.