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Article

Shared B cell memory to coronaviruses and other pathogens varies in human age groups and tissues

12 Apr 2021

Abstract excerpt

Vaccination and infection promote the formation, tissue distribution, and clonal evolution of B cells, which encode humoral immune memory. We evaluated pediatric and adult blood and deceased adult organ donor tissues to determine convergent antigen-specific antibody genes of similar sequences shared between individuals. B cell memory varied for different pathogens. Polysaccharide antigen-specific clones were not...

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PMID: 33846272
DOI: 10.1126/science.abf6648

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