Article
Accelerated DNA replication fork speed due to loss of R-loops in myelodysplastic syndromes with SF3B1 mutation.
Nature communications - 8 Apr 2024
Rombaut David, Lefèvre Carine, Rached Tony, Bondu Sabrina, Letessier Anne, Mangione Raphael M, Farhat Batoul, Lesieur-Pasquier Auriane, Castillo-Guzman Daisy, Boussaid Ismael, Friedrich Chloé, Tourville Aurore, De Carvalho Magali, Levavasseur Françoise, Leduc Marjorie, Le Gall Morgane, Battault Sarah, Temple Marie, Houy Alexandre, Bouscary Didier, Willems Lise, Park Sophie, Raynaud Sophie, Cluzeau Thomas, Clappier Emmanuelle, Fenaux Pierre, Adès Lionel, Margueron Raphael, Wassef Michel, Alsafadi Samar, Chapuis Nicolas, Kosmider Olivier, Solary Eric, Constantinou Angelos, Stern Marc-Henri, Droin Nathalie, Palancade Benoit, Miotto Benoit, Chédin Frédéric, Fontenay Michaela
Abstract excerpt
Myelodysplastic syndromes (MDS) with mutated SF3B1 gene present features including a favourable outcome distinct from MDS with mutations in other splicing factor genes SRSF2 or U2AF1. Molecular bases of these divergences are poorly understood. Here we find that SF3B1-mutated MDS show reduced R-loop formation predominating in gene bodies associated with intron retention reduction, not found in U2AF1- or...
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