Article

Human CCL3L1 copy number variation, gene expression, and the role of the CCL3L1-CCR5 axis in lung function

2018-04-30

Abstract excerpt

<h4>Background: </h4> The CCL3L1-CCR5 signaling axis is important in a number of inflammatory responses, including macrophage function, and T-cell-dependent immune responses. Small molecule CCR5 antagonists exist, including the approved antiretroviral drug maraviroc, and therapeutic monoclonal antibodies are in development. Repositioning of drugs and targets into new disease areas can accelerate the availability o...

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Literature Corpus work: b0ca3511-f374-5e25-9e5a-476bf754d951
DOI: 10.12688/wellcomeopenres.13902.2

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