Article
Copy number variation of CCL3L1 influences asthma risk by modulating IL-10 expression.
Clinica chimica acta; international journal of clinical chemistry - 20 Nov 2011
Lee Haeyong, Bae Sungmin, Choi Byoung Whui, Choi Jae Chol, Yoon Yoosik
Abstract excerpt
BACKGROUND: Copy number of Chemokine ligand 3-like 1 (CCL3L1) is associated with various immune disorders. This study was conducted to assess the role of CCL3L1 in asthma by both association analyses of human subjects and in vitro functional analyses. METHODS: We analyzed the copy number of the CCL3L1 gene in 533 Korean subjects (372 controls and 161 asthma patients) by real-time PCR, and investigated the effect...
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