Article
Lower copy numbers of the chemokine CCL3L1 gene in patients with chronic hepatitis C.
Journal of hepatology - 1 Feb 2010
Grünhage Frank, Nattermann Jacob, Gressner Olav A, Wasmuth Hermann E, Hellerbrand Claus, Sauerbruch Tilman, Spengler Ulrich, Lammert Frank
Abstract excerpt
BACKGROUND & AIMS: Recently, variation of gene copy numbers was recognized as a novel type of common genetic diversity, but its impact on viral hepatitis is unknown. Here, we determine the influence of copy number variation on the susceptibility and disease severity in hepatitis C virus (HCV) infection, investigating copy number variants (CNVs) of the chemokine CCL3L1 gene, which encodes a potent CCR5 ligand....
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