Article
CCL3L1 copy number, CCR5 genotype and susceptibility to tuberculosis.
BMC medical genetics - 9 Jan 2014
Carpenter Danielle, Taype Carmen, Goulding Jon, Levin Mike, Eley Brian, Anderson Suzanne, Shaw Marie-Anne, Armour John A L
Abstract excerpt
BACKGROUND: Tuberculosis is a major infectious disease and functional studies have provided evidence that both the chemokine MIP-1α and its receptor CCR5 play a role in susceptibility to TB. Thus by measuring copy number variation of CCL3L1, one of the genes that encode MIP-1α, and genotyping a functional promoter polymorphism -2459A > G in CCR5 (rs1799987) we investigate the influence of MIP-1α and CCR5,...
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