Article

What scRNA sequencing taught us about MGMT expression in glioblastoma

2024-07-24

Abstract excerpt

<h4>Introduction</h4> The promoter methylation status of O-6-methylguanine-DNA methyltransferase (MGMTp) is an established predictive and prognostic marker in GBM. Previous studies showed that the expression of MGMT based on immunohistochemistry was variable and lacked association with survival. This in part is because non-tumor cells including endothelial cells and macrophages express MGMT. Advanced technologies...

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Literature Corpus work: af540b14-e3cd-53b1-a341-e89c8dad5ee5
DOI: 10.1101/2024.07.23.604798

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