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Common pathogenic mechanisms in the hippocampus across neurodegenerative dementias: Alzheimer's disease, Down syndrome, and Parkinson's disease

2025-10-27

Abstract excerpt

<title>Abstract</title> <p>Extensive evidence suggests overlapping pathological mechanisms in the brain of individuals with Parkinson´s disease dementia, Down syndrome dementia, and Alzheimer´s disease. For these neurodegenerative dementias, we observed that the chronological age did not align with their biological age, which was determined based on hippocampal transcript levels (i.e., transcriptional age). Subse...

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Literature Corpus work
af08c871-a81e-5498-a052-e75f0953c480
DOI
10.21203/rs.3.rs-7703742/v1
Open publication

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Common pathogenic mechanisms in the hippocampus across neurodegenerative dementias: Alzheimer's disease, Down syndrome, and Parkinson's diseaseDOI 10.21203/rs.3.rs-7703742/v1
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