Article

Alu-Mediated Duplication and Deletion of Exon 11 Are a Frequent Mechanism of PALB2 Inactivation Predisposing to Hereditary Breast-Ovarian Cancer Syndrome

2024-10-16

Abstract excerpt

Large genomic rearrangements of PALB2 gene, particularly deletions and duplications, have been linked to hereditary breast-ovarian cancer. Our research specifically focuses on delineating the intronic breakpoints associated with rearrangements of PALB2 exon 11, which is crucial for understanding the mechanisms underlying these genomic changes in patients with hereditary breast and ovarian syndrome. By next-generat...

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Literature Corpus work: aefabae6-f37a-5f45-ba82-8981c2eab640
DOI: 10.20944/preprints202410.1311.v1

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Alu-Mediated Duplication and Deletion of Exon 11 Are a Frequent Mechanism of PALB2 Inactivation Predisposing to Hereditary Breast-Ovarian Cancer SyndromeDOI 10.20944/preprints202410.1311.v1Read

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