Article

Investigation of molecular mechanisms regulating drug-drug interactions in antiretroviral therapy

2019-01-01

Abstract excerpt

Antiretroviral therapy is challenging due to the drug-drug interactions (DDIs) arising from the co-medications administered to treat co-morbidities and opportunistic infections. Drugs causing induction/inhibition of enzymes and transporters, or displacement from plasma proteins can alter drug pharmacokinetics (PK) and result in treatment failure due to elevated toxicities or suboptimal efficacy. Furthermore, inter...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: aed0f910-4d5f-5bd1-9212-cb93e1b58b6a
DOI: 10.17638/03035115

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Investigation of molecular mechanisms regulating drug-drug interactions in antiretroviral therapyDOI 10.17638/03035115Read

Approaches for understanding and predicting drug interactions in human immunodeficiency virus-infected patientsSemantic proximity Read

Pharmacogenomics of Antiretroviral Drug Metabolism and TransportSemantic proximity Read

The dual role of pharmacogenetics in HIV treatment: mutations and polymorphisms regulating antiretroviral drug resistance and disposition.Semantic proximity Read

Pharmacogenetics of antiretroviral drugs for the treatment of HIV-infected patients: An updateSemantic proximity Read

Role and modulation of drug transporters in HIV-1 therapySemantic proximity Read

The role of drug disposition genes for variability in the pharmacokinetics of antiretroviral drugsSemantic proximity Read

Antiretroviral therapy 2006: pharmacology, applications, and special situations.Semantic proximity Read

Pharmacogenomics of antiretrovirals.Semantic proximity Read

Pharmacogenetics of non-nucleoside reverse transcriptase inhibitors (NNRTIs) in resource-limited settings: Influence on antiretroviral therapy response and concomitant anti-tubercular, antimalarial and contraceptive treatments.Semantic proximity Read

Pharmacokinetic Parameters of HIV-1 Protease Inhibitors.Semantic proximity Read

Pharmacogenetics of antiretroviral therapy.Semantic proximity Read

Genetic Polymorphisms Affecting the Pharmacokinetics of Antiretroviral DrugsSemantic proximity Read