Article
Pharmacogenomics of antiretrovirals.
Recent patents on anti-infective drug discovery - 1 Jun 2008
Roca Bernardino
Abstract excerpt
HIV infection is a serious but treatable disease, yet current treatment is limited by development of resistance and high rates of adverse drug reactions. Antiretroviral therapy is especially suitable for pharmacogenomic investigation as both drug exposure and treatment response can be reliably measured. Increasing knowledge about genes implicated in pharmacokinetics, mode of action, efficacy, and toxicity of...
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