Article

Genome-wide Associations, Polygenic Risk, and Mendelian Randomization Reveal Limited Interactions between John Henryism and Cynicism

2022-12-14

Abstract excerpt

Chronic occupational stress and an individual’s reaction to that stress often lead to burnout syndrome. We sought to use genetics to evaluate what, if any, interactions exist between John Henryism (JH) and cynicism in hopes of clarifying holistic risk factors of burnout syndrome. We performed genome-wide association studies in a discover phase with 1,852 samples and validated associations in a replication phase of...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ae772a10-8da7-5097-a7a0-e3f49c9686a2
DOI: 10.1101/2022.12.12.22283345

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genome-wide Associations, Polygenic Risk, and Mendelian Randomization Reveal Limited Interactions between John Henryism and CynicismDOI 10.1101/2022.12.12.22283345Read

Toward Understanding Genetic Risk of Burnout through Genome-wide Associations of Cynicism and Cynical DistrustSemantic proximity Read

Genetic variation mediating neuroticism's influence on cardiovascular diseases.Semantic proximity Read

Genome-wide association study of John Henryism in the CARDIA Cohort suggests a molecular mechanism behind lower nicotine addiction ratesSemantic proximity Read

“The Heidelberg Five” Personality Dimensions: Genome-wide Associations, Polygenic Risk for Neuroticism, and Psychopathology 20 Years after AssessmentSemantic proximity Read

Causal influences of neuroticism on mental health and cardiovascular disease.Semantic proximity Read

Genome-wide association uncovers shared genetic effects among personality traits and mood states.Semantic proximity Read

Hostility in adolescents and adults: a genome-wide association study of the Young Finns.Semantic proximity Read

"The Heidelberg Five" personality dimensions: Genome-wide associations, polygenic risk for neuroticism, and psychopathology 20 years after assessment.Semantic proximity Read

A genome-wide association study of occupational creativity and its relations with well-being and career success.Semantic proximity Read

A Two-Sample Mendelian Randomization Study of Neuroticism and Sleep Bruxism.Semantic proximity Read

Personality GeneticsSemantic proximity Read

Gene-based association analysis identified 190 genes with polymorphisms affecting neuroticismSemantic proximity Read