Article

Normative brain-state trajectories reveal deviation from healthy aging in Alzheimer's disease

2026-06-24

Abstract excerpt

Distinguishing healthy brain aging from early neurodegenerative disruption remains a major challenge in Alzheimer's disease. Here, we used resting-state fMRI from the Alzheimer's Disease Neuroimaging Initiative to model large-scale brain-state dynamics relative to a cognitively normal aging reference. A Hidden Markov Model trained exclusively on cognitively normal adults defined latent connectivity states, and a g...

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Literature Corpus work: ae5ab659-37b8-5a87-875a-ad4679d20300
DOI: 10.64898/2026.06.19.733190

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