Back to search

Article

Distinct molecular profiles characterize the spontaneous growth rate of IDHmt low-grade astrocytoma and oligodendroglioma, WHO grade 2

2025-10-23

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> The life expectancy of patients with diffuse IDH-mutant low-grade gliomas (IDHmt LGG) WHO grade 2 ranges from 5 to over 20 years. Tumor behavior, including spontaneous growth rate, varies even within homogeneously classified subtypes of oligodendroglioma and astrocytoma. Risk-adjusted treatment strategies are needed to avoid therapy-related toxicities, without compromising o...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
ae47f4d1-cb80-5ede-9db6-a58c75ac29d3
DOI
10.1101/2025.10.21.25338454
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Distinct molecular profiles characterize the spontaneous growth rate of IDHmt low-grade astrocytoma and oligodendroglioma, WHO grade 2DOI 10.1101/2025.10.21.25338454
Distinct molecular profiles characterize the spontaneous growth rate of IDHmt low-grade astrocytomas and oligodendrogliomas.Semantic proximity
DNA methylation, transcriptome and genetic copy number signatures of diffuse cerebral WHO grade II/III gliomas resolve cancer heterogeneity and developmentSemantic proximity
Molecular Characterization of “True” Low-Grade IDH-Wildtype AstrocytomasSemantic proximity
Multi-omics characterization of IDH-mutant astrocytoma-derived cell lines reveals NOTCH-regulated plastic quiescent astrocyte-like state and insights into progressionSemantic proximity
Determinants of long-term survival in patients with IDH-mutant gliomas.Semantic proximity
The Cancer Genome Atlas expression profiles of low-grade gliomas.Semantic proximity
Multi-omics characterization of IDH-mutant astrocytoma-derived cell lines reveals NOTCH-regulated plastic quiescent astrocyte-like stateSemantic proximity
Survival of diffuse astrocytic glioma, IDH1/2 wildtype, with molecular features of glioblastoma, WHO grade IV: a confirmation of the cIMPACT-NOW criteriaSemantic proximity
Survival and low-grade glioma: the emergence of genetic informationSemantic proximity
Single-cell and spatial transcriptome sequencing analysis reveals characteristics of a unique subpopulation in high-grade IDH-mutant astrocytoma.Semantic proximity
Combined <i>MGMT</i> Expression and MMR Deficiency Underlie Poor Outcomes of Temozolomide in <i>IDH</i> -Wildtype Grade 2 GliomasSemantic proximity
Association of tumor growth rates with molecular biomarker status: a longitudinal study of high-grade glioma.Semantic proximity
Select a neighboring publication to make it the new centre.