Article

Beyond point estimates: quantifying predictive uncertainty reveals hidden dimensions of biological age acceleration and improves risk interpretation

2026-08-05

Abstract excerpt

Biological age estimates are increasingly used to study aging, disease risk, and mortality, yet their predictive uncertainty is rarely quantified. Consequently, conventional age-gap measures can treat deviations as equally informative even when the underlying biological age predictions differ substantially in reliability. We developed a framework for uncertainty-aware biological aging that generates calibrated pre...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a0181836-d241-582e-a8c0-a2d614c306ea
DOI: 10.64898/2026.08.05.742349

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Beyond point estimates: quantifying predictive uncertainty reveals hidden dimensions of biological age acceleration and improves risk interpretationDOI 10.64898/2026.08.05.742349Read

Proteomic aging clock (PAC) predicts age-related outcomes in middle-aged and older adultsSemantic proximity Read

Refining the generation, interpretation, and application of multi-organ, multi-omics biological aging clocksSemantic proximity Read

Proteome-aware organ proxy aging clocksSemantic proximity Read

Making Biological Ageing Clocks PersonalSemantic proximity Read

A Residual Approach to Estimate Biological Age from Gompertz ModelingSemantic proximity Read

Multi-organ metabolome biological age implicates cardiometabolic conditions and mortality risk.Semantic proximity Read

Blood Omics Models for System-Specific Mortality Risk EstimationSemantic proximity Read

Associations of proteomic age with mortality and incident chronic diseases in the European Prospective Investigation into Cancer and Nutrition (EPIC)Semantic proximity Read

LinAge2: providing actionable insights and benchmarking with epigenetic clocksSemantic proximity Read

A catalogue of omics biological ageing clocks reveals substantial commonality and associations with disease riskSemantic proximity Read

Multi-organ metabolome biological age implicates cardiometabolic conditions and mortality riskSemantic proximity Read

An explainable AI framework for interpretable biological ageSemantic proximity Read