Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Alkyl-glycerol rescues plasmalogen levels and pathology of ether-phospholipid deficient mice.

PloS one - 1 Jan 2011

Brites Pedro, Ferreira Ana Sofia, da Silva Tiago Ferreira, Sousa Vera F, Malheiro Ana R, Duran Marinus, Waterham Hans R, Baes Myriam, Wanders Ronald J A

Abstract excerpt

A deficiency of plasmalogens, caused by impaired peroxisomal metabolism affects normal development and multiple organs in adulthood. Treatment options aimed at restoring plasmalogen levels may be relevant for the therapy of peroxisomal and non-peroxisomal disorders. In this study we determined the in vivo efficacy of an alkyl glycerol (AG), namely, 1-O-octadecyl-rac-glycerol, as a therapeutic agent for defects in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animal Feed
Share to Electrophysiology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glycerol

Share to Lipids

Share to Mice, Knockout

Share to Neural Conduction

Share to Phospholipids

Share to Receptors, Cytoplasmic and Nuclear

Source

Open in PubMed Open full text

Identifiers

PMID: 22163031
DOI: 10.1371/journal.pone.0028539
PMCID: PMC3232224

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Alkyl-glycerol rescues plasmalogen levels and pathology of ether-phospholipid deficient mice.PMID 22163031Read ↗

Oral administration of a synthetic vinyl-ether plasmalogen normalizes open field activity in a mouse model of rhizomelic chondrodysplasia punctataSemantic proximity Read ↗

A Pex7 hypomorphic mouse model for plasmalogen deficiency affecting the lens and skeleton.Semantic proximity Read ↗

Beyond the surface: plasmalogens are dispensable for retinal integrity and fertility in the mouseSemantic proximity Read ↗

Plasmalogens and fatty alcohols in rhizomelic chondrodysplasia punctata and Sjögren‐Larsson syndromeSemantic proximity Read ↗

Mild reduction of plasmalogens causes rhizomelic chondrodysplasia punctata: functional characterization of a novel mutation.Semantic proximity Read ↗

Homeostasis of phospholipids - The level of phosphatidylethanolamine tightly adapts to changes in ethanolamine plasmalogens.Semantic proximity Read ↗

Impaired neuronal migration and endochondral ossification in Pex7 knockout mice: a model for rhizomelic chondrodysplasia punctata.Semantic proximity Read ↗

Impaired membrane traffic in defective ether lipid biosynthesis.Semantic proximity Read ↗

Rhizomelic chondrodysplasia punctata and cardiac pathology.Semantic proximity Read ↗

Interplay between cardiolipin and plasmalogens in Barth syndrome.Semantic proximity Read ↗

Defective lipid remodeling of GPI anchors in peroxisomal disorders, Zellweger syndrome, and rhizomelic chondrodysplasia punctata.Semantic proximity Read ↗

Etherphospholipid biosynthesis and dihydroxyactetone-phosphate acyltransferase: resolution of the genomic organization of the human gnpat gene and its use in the identification of novel mutations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.