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Identification of candidate genes and chemicals associated with osteoarthritis by transcriptome-wide association study and chemical-gene interaction analysis

25 Sept 2023

Abstract excerpt

BACKGROUND: Osteoarthritis (OA) is a common degenerative joint disease and causes chronic pain and disability to the elderly. Several risk factors are involved, such as aging, obesity, genetic susceptibility, and environmental factors. We conducted a transcriptome-wide association study (TWAS) and chemical-related gene set enrichment analysis (CGSEA) to investigate the susceptibility genes and environmental...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 37749624
DOI: 10.1186/s13075-023-03164-x

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