Article

Multi-omic landscaping of human midbrains identifies neuroinflammation as major disease mechanism in advanced-stage Parkinson’s disease

2021-06-12

Abstract excerpt

Parkinson’s disease (PD) is the second most common neurodegenerative disorder whose prevalence is rapidly increasing worldwide. The disease mechanisms of sporadic PD are not yet completely understood. Therefore, causative therapies are still lacking. To obtain a more integrative view of disease-mediated alterations, we investigated the molecular landscape of PD in human post-mortem midbrains. Tissue from 13 PD pat...

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Literature Corpus work: 54b5c223-c62d-5dde-b167-7e2eabc6f784
DOI: 10.1101/2021.06.08.21258527

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