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JS-K, a glutathione/glutathione S-transferase-activated nitric oxide donor of the diazeniumdiolate class with potent antineoplastic activity.

Molecular cancer therapeutics - 1 Apr 2003

Shami Paul J, Saavedra Joseph E, Wang Lai Y, Bonifant Challice L, Diwan Bhalchandra A, Singh Shivendra V, Gu Yijun, Fox Stephen D, Buzard Gregory S, Citro Michael L, Waterhouse David J, Davies Keith M, Ji Xinhua, Keefer Larry K

Abstract excerpt

We have previously shown that nitric oxide (NO) inhibits growth and induces differentiation and apoptosis in acute myeloid leukemia cells, with the HL-60 human myeloid leukemia line being particularly sensitive to NO-mediated cytolysis. With the goal of identifying a prodrug that can target NO to...

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PMID: 12700285

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12700285-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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