Article

The ATP-bound State of the Uncoupling Protein 1 (UCP1) from Molecular Simulations

2023-03-20

Abstract excerpt

The uncoupling protein 1 (UCP1) dissipates the transmembrane (TM) proton gradient in the inner mitochondrial membrane (IMM) by leaking protons across the membrane, producing heat in the process. Such non-shivering production of heat in brown adipose tissue can combat obesity-related diseases. UCP1 associated proton leak is activated by free fatty acids and inhibited by purine nucleotides. The mechanism of proton l...

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Literature Corpus work: ad684c8c-cfb4-5671-ad2a-dbfc9647884b
DOI: 10.1101/2023.03.17.533074

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