Article

Activating ligands of Uncoupling protein 1 identified by rapid membrane protein thermostability shift analysis

2022-02-03

Abstract excerpt

Uncoupling protein 1 (UCP1) catalyzes mitochondrial proton leak in brown adipose tissue for heat production, and may combat metabolic disease if activated in humans. During the adrenergic stimulation of brown adipocytes, free fatty acids generated from lipolysis activate UCP1 via an unclear interaction. Here, we have utilized membrane protein thermostability shift analysis to characterize the interaction of activa...

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Literature Corpus work: 75bea5a4-60f2-5793-bbad-4da17065dbe3
DOI: 10.1101/2022.02.03.478984

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