Article
A single mutation in uncoupling protein of rat brown adipose tissue mitochondria abolishes GDP sensitivity of H+ transport.
The Journal of biological chemistry - 11 Mar 1994
Murdza-Inglis D L, Modriansky M, Patel H V, Woldegiorgis G, Freeman K B, Garlid K D
Abstract excerpt
The uncoupling protein is one of a family of mitochondrial transport proteins involved in energy metabolism. It dissipates oxidative energy to generate heat, either by catalyzing proton transport directly or by catalyzing fatty acid anion transport, thus enabling fatty acids to act as cycling protonophores. This transport process is tightly regulated by purine nucleotides. We have expressed uncoupling protein in...
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