Article

Proximity-ligation metagenomics reveals disease-specific mobilome dynamics in disrupted gut ecosystems

2026-03-25

Abstract excerpt

<title>Abstract</title> <p>Distinct ecological pressures shape accumulation of antimicrobial resistance and virulence genes in the gut microbiome. Using proximity ligation shotgun metagenomics to resolve host–mobilome relationships, we analyzed microbiomes from two patient cohorts: recurrent Clostridioides difficile infection (rCDI) and cirrhosis. While rCDI reflects antibiotic-driven disruption, cirrhosis-driven...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ad65036a-b574-5dab-b8dd-2a5d7a933907
DOI: 10.21203/rs.3.rs-9142184/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Proximity-ligation metagenomics reveals disease-specific mobilome dynamics in disrupted gut ecosystemsDOI 10.21203/rs.3.rs-9142184/v1Read

Linking the resistome and plasmidome to the microbiomeSemantic proximity Read

Linking the Resistome and Plasmidome to the MicrobiomeSemantic proximity Read

Decoding the microbiome and resistome of advanced chronic liver disease through long-read metagenomicsSemantic proximity Read

Shotgun Metagenomics Unravels the Bacterial Diversity, Resistome Profile and Genetic Exchange in a Tropical Urban EnvironmentSemantic proximity Read

Deep longitudinal lower respiratory tract microbiome profiling reveals genome-resolved functional and evolutionary dynamics in critical illnessSemantic proximity Read

Gut metatranscriptome–virome profiling reveals active antimicrobial peptides (AMPs) encoded in plasmids and phages linked to human diseasesSemantic proximity Read

Metagenomics reveals impact of geography and acute diarrheal disease on the Central Indian human gut microbiomeSemantic proximity Read

Pathogenic entero- and salivatypes harbour changes in microbiome virulence and antimicrobial resistance genes with increasing chronic liver disease severitySemantic proximity Read

Hi-C Metagenomics in the ICU: Exploring Clinically Relevant Features of Gut Microbiome in Chronically Critically Ill PatientsSemantic proximity Read

Engrafting gut bacteriophages have potential to modulate microbial metabolism in fecal microbiota transplantationSemantic proximity Read

A Plasmid Network from the Gut Microbiome of Semi-isolated Human Groups Reveals Unique and Shared Metabolic and Virulence TraitsSemantic proximity Read

Deep longitudinal lower respiratory tract microbiome profiling reveals genome-resolved functional and evolutionary dynamics in critical illnessSemantic proximity Read