Article

Two-step Randomisation: Applying the Results of Small Feasibility Studies of Interventions to Large-scale Mendelian Randomisation Studies to Robustly Infer Causal Effects on Clinical Endpoints

2019-10-24

Abstract excerpt

<h4>Background: </h4> Feasibility trials are preliminary trials that assess the viability and acceptability of intervention studies and the effects of the intervention on intermediate endpoints. Due to their short duration, they are unable to establish the effects of the intervention on long-term clinical outcomes. We propose a novel method that could transform the interpretation of feasibility trials using modifi...

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Literature Corpus work: ad564971-9c36-588c-9d38-83ed4650c9c1
DOI: 10.20944/preprints201910.0276.v1

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Two-step Randomisation: Applying the Results of Small Feasibility Studies of Interventions to Large-scale Mendelian Randomisation Studies to Robustly Infer Causal Effects on Clinical EndpointsDOI 10.20944/preprints201910.0276.v1Read

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