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Article

Superantigenic character of an insert unique to SARS-CoV-2 spike supported by skewed TCR repertoire in patients with hyperinflammation.

Proceedings of the National Academy of Sciences of the United States of America - 13 Oct 2020

Cheng Mary Hongying, Zhang She, Porritt Rebecca A, Noval Rivas Magali, Paschold Lisa, Willscher Edith, Binder Mascha, Arditi Moshe, Bahar Ivet

Abstract excerpt

Multisystem Inflammatory Syndrome in Children (MIS-C) associated with COVID-19 is a newly recognized condition in children with recent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. These children and adult patients with severe hyperinflammation present with a constellation of symptoms that strongly resemble toxic shock syndrome, an escalation of the cytotoxic adaptive immune response...

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Identifiers

PMID: 32989130
DOI: 10.1073/pnas.2010722117
PMCID: PMC7568239

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