Lipid-stabilized ICG Nanoaggregates for the Photodisruption of Vitreous Opacities

Abstract excerpt

Collagen aggregation in the vitreous is a major cause of vision impairment. Current treatments such as vitrectomy or YAG laser vitreolysis remain limited by invasiveness and safety concerns. In previous work, we introduced a novel approach combining indocyanine green (ICG) with nanosecond laser pulses to achieve photodisruption of collagen aggregates via vapor nanobubbles (VNBs), while using a significantly lower...

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• Angiogenesis Inhibitors
• Chitosan
• Human Umbilical Vein Endothelial Cells
• Hypoxia-Inducible Factor 1, alpha Subunit
• Nanoparticles
• Retina
• Retinal Pigment Epithelium
• Vascular Endothelial Growth Factor A

Identifiers and source

Literature Corpus work

ad3216a9-8418-553c-b491-5166679e9fe2

DOI

10.1101/2025.09.15.675130