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An Engineered Contact Lens for Passive and Sustained Release of Lifitegrast, an Anti-Dry Eye Syndrome Drug

2021-04-11

Abstract excerpt

<h4>ABSTRACT</h4> Lifitegrast is an FDA-approved drug that inhibits T-cell mediated inflammation associated with dry eye syndrome (DES). Lifitegrast is a potent inhibitor of the interaction between LFA-1 on T-cells and ICAM-1 on endothelial cells at the ocular surface. While effective in treating DES, 5% (81.2 mM) lifitegrast has low drug utilization and elicits off-target effects. Here we engineer contact lenses...

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Literature Corpus work
5d6f40c1-5938-5739-94d8-aacfa1d7dd5b
DOI
10.1101/2021.04.10.439289
Open publication

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