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Article

Suppressing angiogenic phenotypes in retinal cell models through light-triggered anti-VEGF release from upconversion nanoparticle-loaded chitosan microgels.

Colloids and surfaces. B, Biointerfaces - 1 Nov 2026

Canbulat Zehra, Yalcin Esra, Eroglu Zafer, Khadra Riyad, Hasanreisoglu Murat, Metin Onder, Kizilel Seda

Abstract excerpt

Anti-VEGF injections are effective for neovascular age-related macular degeneration (nAMD) but require frequent intravitreal dosing and provide limited spatiotemporal control. We engineered injectable chitosan-methacrylate (ChiMA) microgels that co-localize upconversion nanoparticles (UCNPs) with a photocaged anti-VEGF peptide to enable on-demand, near-infrared (980 nm)-triggered release. Colloidal UCNPs...

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PMID: 42372461
DOI: 10.1016/j.colsurfb.2026.115936

Genes

RPE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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