Microbiota depletion promotes human rotavirus replication in an adult mouse model

Abstract excerpt

<h4>Summary</h4> The study of human rotavirus (RV) infectivity in vivo has been limited by the lack of small animal models able to efficiently replicate the principal human RV genotypes. In recent years, intestinal microbiota-virus-host interaction has emerged as a key factor in mediating enteric virus pathogenicity. With the aim of developing an adult mouse infection model for RV we performed faecal microbiota...

Topics

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• Administration, Oral
• Clostridium difficile and Clostridium perfringens research
• Developing Countries
• Gastrointestinal Microbiome
• Gastrointestinal Tract
• Immunity, Mucosal
• Rotavirus Infections
• Viral gastroenteritis research and epidemiology

Identifiers and source

Literature Corpus work

ac93cba9-9d06-5d9a-aa7b-497f8ab42997

DOI

10.1101/2021.04.15.439998