Article

β-Elemene Prevented Multidrug Resistance of Small Cell Lung Cancer Cell Line H446: Targeting the Autophagy Regulation of MiR-199a-5p is the Mechanism of Cisplatin Resistance.

2021-05-05

Abstract excerpt

<title>Abstract</title> <bold>Background</bold> Multidrug resistance (MDR) in small cell lung cancer (SCLC) is a clinical dilemma in chemotherapy. A natural compound, β-elemene has been found to inhibit MDR cancers. We hypothesized that β-elemene regulated cisplatin-resistant SCLC by targeting autophagy-related miRNA miR-199a-5p. <bold>Methods </bold>We assessed the IC50 of multiple chemotherapeutic...

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Literature Corpus work: ac6536a2-659a-5c77-a2bb-faff5566b098
DOI: 10.21203/rs.3.rs-444506/v1

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