Article

MiR-4458 Regulates Autophagy and Apoptosis By Targeting P53 In Chronic Obstructive Pulmonary Disease.

2021-11-29

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>Chronic obstructive pulmonary disease (COPD) is a progressive chronic airway disease of which tobacco smoking is a main risk factor. Numerous studies have revealed that microRNAs participate in the pathogenesis of COPD by regulating cell autophagy and apoptosis. The goal of this study was to elucidate the potential mechanism of miR-4458 in COPD. <bold>Methods:</...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 63019c00-0bac-5352-bc63-4558931896fc
DOI: 10.21203/rs.3.rs-1089877/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

MiR-4458 Regulates Autophagy and Apoptosis By Targeting P53 In Chronic Obstructive Pulmonary Disease.DOI 10.21203/rs.3.rs-1089877/v1Read

Exosomal miR-380 derived from alveolar macrophages in COPD is involved in enhanced proliferation of human bronchial epithelial cellsSemantic proximity Read

Transcriptomic profiles of single-cell autophagy-related genes (ATGs) in lung diseasesSemantic proximity Read

MiR-449a regulates autophagy to inhibit silica-induced pulmonary fibrosis through targeting Bcl2Semantic proximity Read

The role of miRNAs in alveolar epithelial cells in emphysemaSemantic proximity Read

Differential miRNA Profiling Reveals miR-4433a-5p as a Key Regulator of Chronic Obstructive Pulmonary Disease Progression via PIK3R2- mediated Phenotypic Modulation.Semantic proximity Read

Inhibition of miR-494-3p alleviates oxidative stress-induced cell senescence and inflammation in the primary epithelial cells of COPD patientsSemantic proximity Read

Identification and validation of aging-related genes in COPD based on bioinformatics analysisSemantic proximity Read

Knockdown of STAU1 inhibits inflammation and autophagy in in vitro chronic obstructive pulmonary disease model by regulating AMPK–mTOR signaling pathwaySemantic proximity Read

Identification and Validation of Autophagy-Related Genes in Chronic Obstructive Pulmonary DiseaseSemantic proximity Read

Autophagy in the Cellular Consequences of Tobacco Smoking: Insights into SenescenceSemantic proximity Read

miRNA-486-5p Promotes COPD Progression by Targeting HAT1 to Regulate the TLR4-Triggered Inflammatory Response of Alveolar MacrophagesSemantic proximity Read

Bioinformatics-based identification of potential microRNA biomarkers in frequent and non-frequent exacerbators of COPD.Semantic proximity Read