Article

β-Elemene prevented cisplatin resistance of small cell lung cancer cell H446 by regulating MiR-199a-5p-mediated autophagy

2022-02-09

Abstract excerpt

<h4>Background: </h4> Multidrug resistance (MDR) in small cell lung cancer (SCLC) is a clinical dilemma in chemotherapy. A natural compound, β-elemene has been found to inhibit MDR cancers. We hypothesized that β-elemene regulated cisplatin-resistant SCLC by targeting autophagy-related miR-199a-5p. <h4>Methods: </h4> We assessed the IC 50 of multiple chemotherapeutic agents toward SCLC cells H446 and MDR SCLC cell...

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Literature Corpus work: 3bfe1eb0-c9ec-5793-98fd-9e596f86faf2
DOI: 10.21203/rs.3.rs-1321845/v1

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