Article

A story of MiR-199a-5p in small cell lung cancer cisplatin resistance

2022-02-09

Abstract excerpt

<h4>Background: </h4> Multidrug resistance (MDR) in small cell lung cancer (SCLC) is a clinical dilemma in chemotherapy. Autophagy has been found to be involved in the MDR of cancers. We hypothesized that miR-199a-5p regulated cisplatin-resistant SCLC by targeting autophagy. <h4>Methods: </h4> We validated the MDR of H446/EP using CCK-8. We tested the binding of miR-199a-5p to p62 using the Dual-Luciferase assay a...

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Literature Corpus work: 1bc091aa-e089-5373-ad52-74515d8dd0be
DOI: 10.21203/rs.3.rs-1321838/v1

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